Genesis 3:16
Verse 16. Unto the woman he said] She being second in the transgression is brought up the second to receive her condemnation, and to hear her punishment: I will greatly multiply, or multiplying I will multiply; i.e., I will multiply thy sorrows, and multiply those sorrows by other sorrows, and this during conception and pregnancy, and particularly so in parturition or child-bearing. And this curse has fallen in a heavier degree on the woman than on any other female. Nothing is better attested than this, and yet there is certainly no natural reason why it should be so; it is a part of her punishment, and a part from which even God's mercy will not exempt her. It is added farther, Thy desire shall be to thy husband -thou shalt not be able to shun the great pain and peril of child-bearing, for thy desire, thy appetite, shall be to thy husband; and he shall rule over thee, though at their creation both were formed with equal rights, and the woman had probably as much right to rule as the man; but subjection to the will of her husband is one part of her curse; and so very capricious is this will often, that a sorer punishment no human being can well have, to be at all in a state of liberty, and under the protection of wise and equal laws. Genesis 22:18
Verse 18. And in thy seed, &c.] We have the authority of St. Paul, Ga 3:8,16,18, to restrain this to our blessed Lord, who was THE SEED through whom alone all God's blessings of providence, mercy, grace, and glory, should be conveyed to the nations of the earth. Genesis 49:10
Verse 10. From Judah the sceptre shall not depart] The Jews have a quibble on the word shebet, which we translate sceptre; they say it signifies a staff or rod, and that the meaning of it is, that "afflictions shall not depart from the Jews till the Messiah comes;" that they are still under affliction and therefore the Messiah is not come. This is a miserable shift to save a lost cause. Their chief Targumist, Onkelos, understood and translated the word nearly as we do; and the same meaning is adopted by the Jerusalem Targum, and by all the ancient versions, the Arabic excepted, which has [Arabic] kazeeb, a rod; but in a very ancient MS. of the Pentateuch in my own possession the word [Arabic] sebet is used, which signifies a tribe. Judah shall continue a distinct tribe till the Messiah shall come; and it did so; and after his coming it was confounded with the others, so that all distinction has been ever since lost. Nor a teacher from his offspring] I am sufficiently aware that the literal meaning of the original mibbeyn raglaiv is from between his feet, and I am as fully satisfied that it should never be so translated; from between the feet and out of the thigh simply mean progeny, natural offspring, for reasons which surely need not be mentioned. The Targum of Jonathan ben Uzziel, and the Jerusalem Targum, apply the whole of this prophecy, in a variety of very minute particulars, to the Messiah, and give no kind of countenance to the fictions of the modern Jews.
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